Download Active Oxygen in Biochemistry by Raymond Y. N. Ho, Joel F. Liebman (auth.), Joan Selverstone PDF

By Raymond Y. N. Ho, Joel F. Liebman (auth.), Joan Selverstone Valentine, Christopher S. Foote, Arthur Greenberg, Joel F. Liebman (eds.)

ISBN-10: 0751402931

ISBN-13: 9780751402933

The box of "Oxygen Activation" has attracted substantial curiosity lately, not just since it provides demanding situations in these fields of simple examine that target to appreciate the elemental features of chemical and organic reactions that contain dioxygen, but in addition due to its wide variety of functional implications in such varied fields as drugs, synthesis of prescription drugs and different natural compounds, fabrics technology, and atmospheric technological know-how. this can be the second one of 2 volumes that target the topic of oxygen activation, the 1st slanted towards chemistry and the second one towards organic chemistry. We deliberate those volumes to be extra common than many monographs of this kind, now not as distinctive summaries of the authors' personal study yet particularly as basic overviews of the sector. Our collection of subject matters was once strongly inspired via our syllabus for a path entitled "Oxygen Chemistry," which folks have two times taught together at UCLA. Definition of significant concerns, horizons, and destiny clients was once a huge aim, and, even supposing absolutely accomplished insurance was once impossible, we think that we have got selected a consultant choice of study themes present to the sphere. we've special this paintings to a various viewers starting from execs in fields from physics to drugs to starting graduate scholars who're attracted to swiftly buying the fundamentals of this field.

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The enzymes that catalyze reactions of dioxygen with substrates not only increase the rates of reaction of substrates with dioxygen but also guide the reactions of dioxygen and substrates along specific reaction pathways that give very specific products. There is every indication that these enzymes generate extremely reactive intermediates that are selective only because the exact site of reaction of oxygen with each substrate is controlled by the mode of substrate binding at the active site. Efforts to mimic biological oxygen activation using model compounds have suggested a number of different reactive intermediates, but, as described below, it is not yet possible to conclude with certainty which one or ones are operating in the case of each individual enzyme.

Nat/. Acad. Sci. , 73, 3333-3337. , and MODENA, G. (1992) Transition Metal Catalyzed Oxidation. The Role of Peroxometal Complexes, in Organic Peroxides (W. ), John Wiley & Sons, New York, 559-598. COTTON, A. , and WILKINSON, G. (1988) Advanced Inorganic Chemistry, 5th edition, John Wiley and Sons, New York. CRUMP, D. , STEPANIAK, R. , and PAYNE, N. C. (1977) Charge Distribution in Dioxygen Complexes of Cobalt(III). The Crystal Structure and Absolute Configuration of (+ )546-~-cis-P-[ {2, 13-Dimethyl-6,9-diphenyl2,6,9, 13-tetraarsatetradecane}(Dioxygen)Cobalt(III)] Perchlorate.

Efforts to mimic biological oxygen activation using model compounds have suggested a number of different reactive intermediates, but, as described below, it is not yet possible to conclude with certainty which one or ones are operating in the case of each individual enzyme. Mechanisms of Dioxygen Activation 21 By dioxygen activation, we mean a mechanistic pathway that causes the properties of the dioxygen molecule to be modified in such a way that the kinetic barriers to its reduction or its reaction with a substrate are lowered.

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